45 Does ovarian endometriosis increase oocyte sensitivity to icsi-induced mechanical damage?

Introduction and aims of the study: Some studies on sibling oocytes have shown that intracytoplasmic sperm injection (ICSI) obtains poorer results than conventional in vitro fertilization (cIVF) women with ovarian endometriosis, suggesting their could be particularly sensitive to some ICSI-induced mechanical damage. Aims this study were clarify (a) whether endometriosis induce peculiar fragility so ICSI would finally result harmful, (b) endometrioma removal before IVF advisable order avoid any hypothetical detrimental effect oocytes. Methods: In present case-control study, data who underwent first cycle between January 2010 December 2018 at Unit S. Anna Hospital, Turin (Italy), retrospectively reviewed. We included 368 women: 203 situ time (128 which 75 cIVF), 165 received laparoscopic stripping undergoing ICSI. Results: For treatment, cIVF outcome was comparable for all studied parameters, including clinical pregnancy rate per embryo transfer (PR/ET: 31.8% (95% confidence interval (CI), 20.8-44.4%) group vs. 39.5% (95%CI, 30.7-48.9%) group, p=0.15) cumulative live birth ovum pick-up (CLBR/OPU: 24.4% 15.6-35.1%) 27.7% (95%CI,20.7-35.7%) p=0.29). also similar comparing (CLPR/OPU: 20.7-35.7%)) previously submitted cyst 25.1% 19.1-32.0%)) (p=0.30). Conclusions: Our findings suggest may performed, when needed, without harming compromising outcome, there is no advantage removing performing